A Sod2 null mutation confers severely reduced adult life span in Drosophila.
نویسندگان
چکیده
A null mutation for the Sod2 gene, Sod2n283, was obtained in Drosophila melanogaster. Homozygous Sod2 null (Sodn283/Sodn283) adult flies survive up to 24 hr following eclosion, a phenotype reminiscent of mice, where Sod2-/- progeny suffer neonatal lethality. Sodn283/+ heterozygotes are sensitive to oxidative stress induced by paraquat treatment.
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عنوان ژورنال:
- Genetics
دوره 165 4 شماره
صفحات -
تاریخ انتشار 2003